Table 3.
Univariate analysis of factors influencing 6-month OS after relapse
| Covariates | N (123) | HR | 95% CI | P value |
|---|---|---|---|---|
| Age at HSCT (years) | ||||
| <=30 | 55 | Ref. | ||
| >30 | 68 | 0.7 | 0.5–1.1 | 0.2 |
|
| ||||
| Sex | ||||
| Female | 39 | Ref. | ||
| Male | 84 | 1.7 | 1.01–2.8 | 0.05 |
| Lineage | ||||
| B-cell | 95 | Ref. | ||
| T-cell | 28 | 1 | 0.6–1.7 | 0.99 |
|
| ||||
| Cytogenetic | ||||
| Ph- | 71 | Ref. | ||
| Ph+ | 28 | 0.7 | 0.4–1.3 | 0.2 |
|
| ||||
| Status at HSCT | ||||
| CR1 | 28 | Ref. | ||
| CR2/CR3 | 55 | 2.02 | 0.9–4.3 | 0.07 |
| Active disease | 40 | 3.1 | 1.4–6.7 | 0.005 |
|
| ||||
| Preparative regimen | ||||
| RIC | 32 | Ref. | ||
| HD | 91 | 1.1 | 0.6–1.8 | 0.8 |
|
| ||||
| Allotype | ||||
| Matched unrelated | 45 | Ref. | ||
| Matched related | 65 | 0.7 | 0.5–1.2 | 0.2 |
| Cord blood | 7 | 0.8 | 0.3–2.2 | 0.6 |
| Mismatched related | 6 | 1.6 | 0.6–4.2 | 0.3 |
|
| ||||
| Time to relapse (months) | ||||
| >6 | 42 | Ref. | ||
| <=6 | 81 | 2.05 | 1.2–3.4 | 0.007 |
|
| ||||
| Site of relapse | ||||
| Systemic | 99 | Ref. | ||
| Isolated extramedullary | 24 | 0.8 | 0.4–1.4 | 0.4 |
*
Palliative group was excluded.
**
Palliative group and non-evaluable patients excluded.
CR indicates complete remission; PIF, primary induction failure; RIC, reduced intensity conditioning; HD, high dose conditioning; NR, no response