Table 9.
Ex vivo permeation data of natamycin (NT) from F1 (optimized NT-Cub dispersed in Carbopol 934 in situ gel base), F2 (optimized NT-Cub dispersed in phosphate buffer pH 5.5), NT suspension, and commercial formulation (Pimafucin) samples.
| Parameters of permeation | F1 | F2 | NT suspension | Commercial formulation |
|---|---|---|---|---|
| Cumulative amount permeated (μg/cm2) | 1613 ± 210†,#,$ | 1101 ± 166@,#,$ | 310 ± 91@,†,$ | 488 ± 68@,†,# |
| Steady-state flux, Jss (μg/cm2·min) | 11.221 | 8.227 | 2.833 | 3.644 |
| Permeability coefficient, Pc (cm/min) | 6.4 × 10−4 | 4.8 × 10−4 | 1.9 × 10−4 | 2.5 × 10−4 |
| Diffusion coefficient, D (cm2/min) | 20.2 × 10−4 | 15.6 × 10−4 | 5.6 × 10−4 | 7.1 × 10−4 |
| Relative permeation rate (RPR) | 3.305 | 2.256 | 0.635 | – |
| Enhancement factor (EF) | 5.203 | 3.551 | – | 1.574 |
Statistical inferences: @p < .05, compared with F1; †p < .05, compared with F2; #p < .05, compared with NT suspension; $p < .05, compared with commercial formulation.