Figure 1.

(a) Volcano plot of differentially expressed miRNAs. Yellow dots represent upregulated miRNAs, and blue dots represent downregulated miRNAs. (b) The heat map shows the top 10 upregulated and top 10 downregulated differentially expressed miRNAs. miR-451a and miR-16-1-3p are included in this heat map. A red box represents upregulated expression, whereas a blue box represents downregulated expression. For log fold change (lfc), red represents upregulated expression, whereas green represents downregulated expression; the colour scale for lfc ranges from −4 (green) to 6 (red), and the x-axis above the plot indicates grouping of samples in which red is the tumour tissue group and blue is the normal tissue group.