Table 3.

Summary of genomic features with sex differences identified in TCGA and PCAWG

Cancer subtype	Mutation density	PGA	Genes with sex-different SNV
Bladder urothelial	Higher in male
Melanoma	Higher in male
Liver hepatocellular	Higher in male		CTNNB1, BAP1
Glioblastoma	Higher in female
Stomach and esophageal	Higher in male (MSI adjusted)	Higher in male	PGM5, GTF3C1, LTBP1, MEGF8, RNF213, EP400, OBSCN, ZFHX3, SLIT2, ZBTB20
Head and neck		Higher in male
Kidney renal cell		Higher in male	BAP1
Sarcoma		Higher in female
Thyroid	Higher inmale (marginal)		TERT
Kidney renal papillary cell			TTN
Long adenocarcinoma			STK11, SMG1, CNTN5, ZNF521, COL21A1, RBM10, ABCB5, FAM47A, DMD, F8, MED12

Data adapted from Li et al (24,25) and Yuan et al (27) with permission from Elsevier.

Abbreviation: MSI, microsatellite instability; PACWG, Pan-cancer Analysis of Whole Genomes; PGA, proportion of the genome with a copy number aberration; SNV, single-nucleotide variant; TCGA, The Cancer Genome Atlas.