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. 2021 Sep 14;18(9):e1003758. doi: 10.1371/journal.pmed.1003758

Table 3. Language requirements in clinical trials by therapeutic area.

Therapeutic area Total Number (percent, 95% CI)
Requires English Accommodates translation Accommodates Spanish* Does not mention any language requirement
Depression 67 35 (52.24, 40.28–64.20) 5 (7.46, 1.17–13.76) 0 (NA) 27 (40.30, 28.55–52.04)
Diabetes 85 25 (29.41, 19.73–39.10) 13 (15.29, 7.64–22.95) 8 (9.41, 3.20–15.62) 47 (55.29, 44.72–65.86)
Breast cancer 70 13 (18.57, 9.46–27.68) 15 (21.43, 11.82–31.04) 5 (7.14, 1.11–13.18) 42 (60.00, 48.52–71.48)
Prostate cancer 55 4 (7.27, 0.41–14.14) 8 (14.55, 5.23–23.86) 0 (NA) 43 (78.18, 67.27–89.10)

*Number of trials specifying Spanish is a subset of the trials accommodating translation.

NA, not applicable.