Box 2.

The International Union of Angiology's guidelines on thrombophilia testing

Patients who should be tested for a thrombophilia Patients who have their first VTE under 40 years of age Patients with oestrogen therapy or pregnancy as the sole risk factor for VTE Patients who have their first unprovoked VTE under 60 years of age Patients with recurrent VTE, irrespective of risk factor presence Patients with recurrent superficial vein thrombosis in the absence of varicose veins Patients with VTE at unusual sites under 50 years of age Patients with warfarin-induced skin necrosis and neonates with purpura fulminans not related to sepsis Asymptomatic individuals with symptomatic first-degree relatives who have thrombophilia

Adapted from International Union of Angiology 2013.⁷