. Author manuscript; available in PMC: 2021 Sep 14.

Published in final edited form as: J Alzheimers Dis. 2020;78(4):1345–1361. doi: 10.3233/JAD-201146

Table 3.

mGluRs in Alzheimer’s disease

mGluR type	Synaptic functions in AD	References
mGluR1	Obstructed mGluR1-LTD contribute to the early stage memory and learning deficits in AD patients	[79, 200, 201]
mGluR5	Shifts towards synapse when Aβ oligomers are around and promotes synaptotoxicity; dysregulation of mGluR5 mediated synaptic events; acts as a co-receptor for Aβ oligomers and prion protein (PrPc) interaction	[202, 203, 205]
mGluR2	Increased synaptic Aβ₄₂ generation; its inhibition in AD mice models improves neurogenesis and synaptic transmission while reducing Aβ toxicity	[138, 177]
mGluR3	Enhanced neuronal firing with mGluR3 stimulation; astrocytic mGluR3 protects against NMDAR mediated excitotoxicity	[174, 204]
mGluR4	Knockouts for mGluR4 exhibit improved LTP in hippocampal CA1 region	[185]
mGluR7	mGluR7 activation protects against NMDA induced excitotoxicity at synapse	[187]
mGluR8	Believed to dampen glutamate excitotoxicity and regulate neurotransmitter release	[181]