Table 4. Outcomes in patients with IC-MPGN stratified by median age (62 y) and with or without steroid pulse therapy at initial treatment.
| ≤ 62y | > 62y | P value | |||
|---|---|---|---|---|---|
| Steroid pulse (-) | Steroid pulse (+) | Steroid pulse (-) | Steroid pulse (+) | ||
| N | 15 | 19 | 23 | 10 | |
| Last urinary protein (g/day)(or g/gCr) | 0.53 (0.08, 0.92) | 0.09 (0.05, 0.43) | 3.15 (1.15, 4.57) | 2.91 (0.26, 4.55) | 0.001* |
| Last serum creatinine (mg/dL) | 0.89 (0.68, 1.79) | 0.87 (0.53, 2.28) | 3.37 (1.33, 5.03) | 1.81 (0.84, 4.85) | 0.005* |
| Last eGFR (mL/min/1.73 m 2 ) | 58.7 ± 35.1 | 67.2 ± 39.9 | 21.9 ± 20.0 ¶ | 34.9 ± 30.2 | 0.001* |
| Last serum albumin (g/dL) | 3.9 ± 0.8 | 3.8 ± 0.8 | 3.1 ± 0.6 ¶ | 3.1 ± 0.8 | 0.004* |
| Complete remission | 2 (13.3) | 9 (47.4) | 2 (8.7) | 2 (20.0) | 0.038* |
| Serum creatinine ×1.5 | 2 (13.3) | 7 (36.8) | 17 (73.9) | 3 (33.3) | 0.002* |
| End-stage kidney disease | 2 (13.3) | 3 (15.8) | 10 (43.5) | 3 (33.3) | 0.092 |
| All-cause death | 1 (6.7) | 1 (5.3) | 7 (30.4) | 3 (13.3) | 0.065 |
Numbers are N (%) or mean ± standard deviation or median (25%, 75%). eGFR, estimated glomerular filtration rate.
*P < 0.05 for chi-square test, or Kruskal–Wallis test, as appropriate (followed by multiple comparison test with the Bonferroni correction).
¶P < 0.05 for comparison of younger patients without steroid pulse therapy.