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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Pharmacol Res. 2021 Jul 24;171:105788. doi: 10.1016/j.phrs.2021.105788

Figure 2. Effects of COX inhibition on ACh-induced relaxation in uterine arteries exposed to PVAT-derived factors in non-pregnant rats.

Figure 2.

(A) All treatments; (B) Concentration-response curves to ACh in the presence or absence of indomethacin (no PVATmedia added); (C) Concentration-response curves to ACh in the presence or absence of indomethacin (PVATmedia added); (D) Maximum responses (Emax) to ACh for all concentration-response curves; (E) Negative logarithm of EC50 (pEC50) for all concentration-response curves; (F) Area under the curve for all concentration-response curves. Values are mean ± SEM. One-way ANOVA followed by Tukey’s post hoc test. ACh, acetylcholine; COX, cyclooxygenase; PVATmedia, perivascular adipose tissue conditioned media.