Table 1.
The Independent Variables Levels Used to Formulate CLT Loaded SPs Utilizing (32) Complete Factorial Design
| Factors (Independent Variables) | Levels | ||
| X1: Span 60: EA ratio (w/w) | 80: 20 | 70: 30 | 60: 40 |
| X2: Type of EA | Tween 80 | Pluronic F127 | Kolliphor RH40 |
| Responses (Dependent Variables) | Desirability Constraints | ||
| Y1: EE% | Maximize | ||
| Y2: VS (nm) | Minimize | ||
| Y3: PDI | Minimize | ||
| Y4: ZP (mV) | Maximize (as absolute value) | ||
Abbreviations: CLT, clotrimazole; SPs, spanlastics; EA, edge activator; EE%, encapsulation efficiency percent; VS, vesicle size; PDI, polydispersity index; ZP, zeta potential.