Fig. 2.

SARS-CoV-2 infection triggers activation of downstream molecules of the ATR DNA damage response. (A) Shows representative image of the western blot showing significant increase in phospho-CHK1 and γH2AX expression in SARS-CoV-2 infected cells. Quantification plots showing relative change in expression of p-ATR, p-CHK1, and γH2AX. (B)Shows representative images of the western blots showing a significant increase in total CHK1 and ATR levels, as well as quantification plots showing relative change in expression of total CHK1 and ATR. Error bars represent standard error of the mean (n=3 for CHK1 and ATR, n = 10 for γH2AX; n = 12 for p-CHK1; n = 13 for p-ATR). ∗P<0.05, ∗∗P<0.005 and ∗∗∗∗P<0.000005.