TABLE 2.
Multivariable cox proportional hazards regression model for the risk of graft failure
| Variable | Estimate | P | Hazard ratio | 95% CI | |
|---|---|---|---|---|---|
| Lower bound | Upper bound | ||||
| Age (y) | −0.01 | 0.30 | 1.00 | 0.99 | 1.01 |
| Male gender (ref: female) | −0.18 | 0.13 | 0.84 | 0.67 | 1.05 |
| Living donor (ref: deceased) | 0.06 | 0.72 | 1.07 | 0.76 | 1.50 |
| Incidental CCA (ref: no) | 0.09 | 0.43 | 1.10 | 0.87 | 1.39 |
| MELD exception (ref: no) | −0.13 | 0.48 | 0.88 | 0.62 | 1.25 |
| Recent era (ref: before January 18, 2010) | −0.20 | 0.30 | 0.82 | 0.57 | 1.19 |
| MELD exception by era interaction effect | 0.18 | 0.44 | 1.19 | 0.77 | 1.86 |
| Laboratory MELD score (ref: <15) | 0.001 | ||||
| 15–19 | 0.32 | 0.03 | 1.37 | 1.02 | 1.83 |
| 20–24 | 0.32 | 0.053 | 1.38 | 0.995 | 1.91 |
| 25–29 | 0.37 | 0.12 | 1.45 | 0.91 | 2.32 |
| 30–34 | 0.03 | 0.93 | 1.03 | 0.49 | 2.19 |
| 35–39 | −0.15 | 0.70 | 0.86 | 0.41 | 1.81 |
| ≥40 | 1.27 | <0.001 | 3.56 | 1.99 | 6.38 |
| Center-level CCA LTs per active year (ref: >12) | <0.001 | ||||
| 1 | 0.85 | <0.001 | 2.33 | 1.52 | 3.57 |
| >1 and ≤2 | 0.66 | <0.001 | 1.93 | 1.41 | 2.65 |
| >2 and ≤4 | 0.58 | 0.002 | 1.78 | 1.24 | 2.58 |
| Waiting time (mo) | 0.00 | 0.81 | 1.00 | 0.99 | 1.01 |
CCA, cholangiocarcinoma; CI, confidence interval; LT, liver transplantation; MELD, Model for End-Stage Liver Disease; ref, reference group.