Table 2.
Registered coumarin clinical trials on the Clinicaltrials.gov database.
| Title | Participants | Type of trial | Period | Outcomes |
|---|---|---|---|---|
| Effectiveness of a Multidisciplinary Medication Review with Follow-up for Patients Treated with Coumarin Anticoagulants in Primary Care NCT03154489 |
204 | Randomized | May 2017-May 2018 | Effectiveness of medication review with follow-up. Principally studying INR control of these patients during 6 months |
| Efficacy and Safety of Coumarin and Troxerutin in the symptomatic Treatment of Chronic Venous Insufficiency NCT01848210 |
829 | Randomized | May 2013-September 2015 | Mean Change (Reduction) from Baseline in Volume of Reference Le g at Week 16 Change in the partial volume of legs will be measured using a water plethysmometer. |
| Efficacy and Safety Study of BERIPLEX® P/N (Kcentra) Compared with Plasma in Patients with Acute Major Bleeding Caused by Anticoagulant Therapy NCT00708435 |
216 | Randomized | - | Percentage of participants achieving hemostatic efficacy of stopping an ongoing major bleed: at 1 and 4 hours after the end of infusion Percentage of participants who had a rapid decrease of the international normalized ratio (INR) time frame: 30 minutes after the end of infusion |
| Anticoagulation in Liver Fibrosis NCT00180674 |
12 | Nonrandomized | August 2005-October 2006 | - |
| An Open-label, Randomized, Multicenter Phase IIIb Study to Assess the Efficacy, Safety and Tolerance of BERIPLEX® P/N (Kcentra) Compared with Plasma for Rapid Reversal of Coagulopathy Induced by Vitamin K Antagonists in Subjects Requiring an Urgent Surgical Procedure (BE1116_3003) NCT00803101 | 176 | Randomized | February 2009-February 2013 | Percentage of participants achieving hemostatic efficacy during surgery the start of infusion until the end of surgery Percentage of participants who had a rapid decrease of the INR: 30 minutes after the end of infusion |
| Therapeutic Equivalence between Branded and Generic WARFArin Tablets in Brazil (WARFA) NCT02017197 | 100 | Randomized | August 2014-August 2016 | Difference between Delta INR at the fourth week of each period |
| Rivaroxaban Compared to Vitamin K Antagonist upon Development of Cardiovascular Calcification NCT02066662 | 192 | Randomized | July 2013-active | Progression of coronary and aortic valve calcification (Agatston, volume & mass score as assessed by cardiac CT) |