Table 2.

Change in the score of the BDI-II, NMSS mood/apathy domain, and PDQ-39 emotional well‐being domain between the visits of the study: V1 (N = 50), V2 (N = 47), V3 (N = 45), V4 (N = 44)

	V1	V2	V3	V4	pa	pb	pc	pd
BDI-II	15.88 ± 10.46	11.86 ± 7.94	10.97 ± 6.24	10.18 ± 6.76	< 0.0001	< 0.0001	< 0.0001	0.297
NMSS—mood/apathy	34.42 ± 29.89	19.47 ± 21.51	16.94 ± 17.29	14.49 ± 19.63	< 0.0001	0.001	< 0.0001	0.112
PDQ-39SI—emotional well‐being	44.3 ± 29.34	31.1 ± 25.17	25.64 ± 20.21	26.33 ± 23.01	< 0.0001	< 0.0001	0.001	0.088
Dose of safinamide (mg/day)	NA	53.84 ± 13.49	96.15 ± 13.49	98.72 ± 8.00

p values were computed using the Wilcoxon signed-rank test. The results represent mean ± SD. NMSS—mood/apathy and PDQ-39SI—emotional well-being domains were expressed as a percentage. Significant values are in bold

BDI-II Beck Depression Inventory-II, NMSS Non-Motor Symptoms Scale, NA not applicable

^aV4 vs V1; ^bV3 vs V1; ^cV2 vs V1; ^dV4 vs V2