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. Author manuscript; available in PMC: 2022 Mar 15.
Published in final edited form as: Neuropharmacology. 2021 Jan 12;186:108452. doi: 10.1016/j.neuropharm.2021.108452

Figure 6.

Figure 6.

Effect of intra-NAc core infusions of MTEP on expression of incubation of cue-induced methamphetamine craving. (A) Self-administration (SA) training data for rats shown in panel B. AH, active hole; IH inactive hole. These data and data in other panels are presented as mean ± SEM. (B) MTEP (1 μg/side) or Veh was infused bilaterally into the NAc core 10 min before a 30-min seeking test using a counterbalanced design in which rats that received vehicle on WD21 received MTEP on WD25, and vice versa (n = 8 rats; paired t-test, p = 0.148 MTEP vs. Veh). (C) Diagrams illustrate the location of cannula tips where injections were made into the NAc core. Coronal sections are adapted from (Paxinos and Watson, 2013); numbers indicate distance from bregma in the anteroposterior plane. (D) Self-administration (SA) training data for rats shown in panel E. (E) Using the same counterbalanced design in early withdrawal (WD1 and WD4), intra-NAc MTEP (1 μg/side) had no effect on AH or IH nose-pokes or locomotor activity (n = 9 rats; paired t-test, p = 0.140 MTEP vs. Veh). (F) Location of cannula tips for rats in panel E (see legend to panel C for details).