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. 2021 Aug 9;41(9):2225–2234. doi: 10.1038/s41372-021-01100-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — A Schematic of WISER study design. Active WISER period shaded gray. Seven assessment points presented in circles: two baseline assessment (A₁ and A₂), two 1-month follow-ups (B and E), two 6-month follow-ups (C and F), and one re-pre (D) that was a second baseline assessment for Cohort 2 for comparison with a 1-month post of Cohort 1. B CONSORT Diagram. Efficacy of WISER intervention: cohort 1 change at 1-month (B–A₁) vs. cohort 2 control (D–A₂). Within-cohort change from baseline to 1-month: B–A for cohort 1; E–D for cohort 2; Within-cohort change from baseline to 6-months: C–A for cohort 1; F–D for cohort 2; Effectiveness comparison of cohort 2 change versus cohort 1 at 1-months: (B–A) vs. (E–D); Effectiveness comparison of cohort 2 change versus cohort 1 at 6-month: (C–A) vs. (F–D).