Table 3.
Cognitive function and psychopathology scores by NMDAR antibody serostatus (descriptive means shown with F and p values from ANOVA).
| Antibody positive | Antibody negative | F (serostatus) | p (serostatus) | |
|---|---|---|---|---|
| NMDAR antibody (IgG, IgA, IgM; fixed assay) | ||||
| AVLT IR total (7:160) | 52.00 ± 13.79 | 63.06 ± 11.90 | 4.817 | 0.030 |
| AVLT IR total (CAARMS adjusted) (5:127) | 45.80 ± 10.69 | 62.50 ± 11.90 | 7.651 | 0.007 |
| WAIS estimated total IQ (9:222) | 84.22 ± 20.35 | 98.71 ± 16.90 | 6.687 | 0.010 |
| WAIS estimated total IQ (CAARMS adjusted) (7:182) | 83.29 ± 21.62 | 100.32 ± 16.86 | 7.134 | 0.008 |
| CAARMS total (9:198) | 49.00 ± 16.17 | 49.49 ± 15.00 | 0.001 | 0.981 |
| BPRS-positive sx (11:224) | 14.91 ± 5.43 | 13.55 ± 4.54 | 0.731 | 0.393 |
| SANS (9:210) | 20.44 ± 15.30 | 15.53 ± 11.74 | 1.074 | 0.301 |
| YMRS (11:225) | 4.27 ± 5.35 | 4.00 ± 4.79 | 0.03 | 0.957 |
| MADRS (11:230) | 20.91 ± 12.98 | 18.69 ± 9.16 | 0.650 | 0.421 |
| NMDAR antibody (IgG; LIVE ASSAY) | ||||
| AVLT IR total (9:158) | 58.00 ± 13.90 | 62.86 ± 12.03 | 0.929 | 0.337 |
| AVLT IR total (CAARMS adjusted) (9:123) | 58.00 ± 13.90 | 62.15 ± 12.13 | 0.826 | 0.365 |
| WAIS estimated total IQ (12:219) | 95.00 ± 19.98 | 98.32 ± 17.10 | 0.067 | 0.796 |
| WAIS estimated total IQ (CAARMS adjusted) (12:177) | 95.00 ± 19.98 | 100.01 ± 17.11 | 0.353 | 0.553 |
| CAARMS total (13:194) | 51.00 ± 11.90 | 49.37 ± 15.21 | 0.197 | 0.657 |
| BPRS-positive sx (13:222) | 14.62 ± 4.82 | 13.56 ± 4.57 | 0.683 | 0.409 |
| SANS (13:206) | 15.31 ± 11.39 | 15.76 ± 11.96 | 0.058 | 0.810 |
| YMRS (12:224) | 6.50 ± 5.16 | 3.89 ± 4.76 | 3.179 | 0.076 |
| MADRS (13:228) | 23.69 ± 9.05 | 18.51 ± 9.30 | 3.847 | 0.051 |
Bold values indicate statistical significance p < 0.05.
Numbers in brackets under variable names are the number of seropositive subjects and seronegative subjects for whom data were available for that variable. BPRS total score excluded from analysis due to heteroscedasticity.
NMDAR N-methyl-d-aspartate receptor, AVLT Rey Auditory Verbal Learning Task, IR immediate recall, CAARMS Comprehensive Assessment of At-Risk Mental States, WAIS Wechsler Adult Intelligence Scale III, BPRS Brief Psychiatric Rating Scale, SANS Scale for the Assessment of Negative Symptoms, YMRS Young Mania Rating Scale, MADRS Montgomery-Asberg Depression Rating Scale.