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. 2020 Mar 16;26(6):2316–2333. doi: 10.1038/s41380-020-0692-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — a The change of mRNA levels of Pdcd4 in the hippocampal (HIP) and prefrontal cortex (PFC) after CRS. No-CRS n = 7–8, CRS n = 7–8; unpaired two-tailed Student’s t test, **P < 0.01. b, c The change of protein levels of Pdcd4 in the HIP and PFC after CRS. For HIP No-CRS n = 6, CRS n = 8, for PFC No-CRS n = 4, CRS n = 4; unpaired two-tailed Student’s t test, **P < 0.01. d Immobility time in TST, e immobility time in FST, and f sucrose consumption in SPT under basal or stress condition. n = 8 per group; mean ± SEM, two-way ANOVA and Sidak’s multiple comparison test, **P < 0.01. g Top, schematic of construct displaying mouse Pdcd4 subcloned into an AAV9 plasmid under transcriptional regulation of the CMV promoter (AAV9-CMV-mPdcd4-P2A-GFP); AAV9-CMV-P2A-GFP served as the control. Bottom, the schematic of the experiment. h Representative photomicrographs of injection sites in the hippocampus. n = 4 per group, Scale bars, 100 µm. i Fold change of Pdcd4 protein from hippocampus microdissections from control (n = 4) or AAV-Pdcd4–injected (n = 3) mice, unpaired two-tailed Student’s t test. j Mean immobility time (±SEM) for control (n = 8) and OE-Pdcd4 (n = 9) animals in the tail suspension test, unpaired two-tailed Student’s t test. k Mean immobility time (±SEM) for control (n = 8) and OE-Pdcd4 (n = 9) animals in the force swimming test, unpaired two-tailed Student’s t test. l Mean sucrose preference (±SEM) for control (n = 8) and OE-Pdcd4 (n = 9) animals, unpaired two-tailed Student’s t test. *P < 0.05 and **P < 0.01.