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. 2021 Feb 17;26(6):1748–1760. doi: 10.1038/s41380-020-01001-0

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — All panels: Left: schematics of behavioural protocols (top) and freezing responses measured during all trials (bottom). PE: 4 h context pre-exposure; CFC contextual fear conditioning comprising Pre-US and Post-US epochs before and after footshock (US), respectively; STM, LTM1, LTM2: short-term and long-term contextual fear memory (CFM) retrieval trials. Right: Summary of freezing responses at LTM tests. A Acquisition and consolidation of CFC are unaltered in Cacna1c^+/− animals. Effects of genotype: F_(1,12) = 0.385, p = 0.546, trial: F_(4,48) = 29.624, p < 0.001; genotype × trial interaction: F_(4,48) = 0.533, p = 0.712; Cacna1c^+/−: n = 6; Cacna1c^+/+: n = 8. B Higher levels of freezing post-US and during CFM retrieval trials indicate the Cacna1c^+/− animals have a deficit in the LI. Genotype × session interaction: F_(2.1,31.49) = 6.119, p = 0.005; pairwise comparisons between genotypes: Post-US: F_(2.1,31.47) = 10.464, p = 0.006; LTM1: F_(2.1,31.49) = 8.895, p = 0.009; LTM2: F_(2.1,31.49) = 9.869, p = 0.007 (Greenhouse–Geisser corrected); Cacna1c^+/−: n = 9; Cacna1c^+/+: n = 8. Data presented as means ± SEM. **p < 0.01 determined by two-way repeated measures ANOVA followed by pairwise post-hoc comparison with Bonferroni correction.