Table 2.
Significant epigenome-wide DNA methylation CpGs associated with phosphatidylethanol (PEth) in the meta-analysis of Cohort 1.
| Probe | CHR | Position | Gene | Group | Incremental adjusted R2 | Discovery | Replication | Meta-analysis | Reference | |||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| t | P value | t | P value | Z score | P value | FDR | ||||||||
| 1 | cg11376147a | 11 | 57261198 | SLC43A1 | Body | 4.49% | −5.18 | 3.28E−07 | −4.48 | 1.00E−05 | −6.75 | 1.46E−11 | 4.94E−06 | [28, 29] |
| 2 | cg13442969 | 12 | 68044208 | DYRK2 | 5UTR | 4.87% | −5.40 | 1.01E−07 | −4.10 | 4.97E−05 | −6.68 | 2.42E−11 | 4.94E−06 | [29] |
| 3 | cg26689780 | 4 | 10079554 | WDR1 | Body | 4.20% | 5.08 | 5.36E−07 | 3.98 | 8.39E−05 | 6.36 | 1.99E−10 | 2.71E−05 | [28] |
| 4 | cg06690548 | 4 | 139162808 | SLC7A11 | Body | 6.40% | −6.24 | 9.47E−10 | −2.45 | 1.48E−02 | −6.21 | 5.46E−10 | 5.57E−05 | [28, 29] |
| 5 | cg17962756 | 5 | 172769199 | NA | NA | 5.25% | −5.58 | 3.98E−08 | −3.04 | 2.56E−03 | −6.12 | 9.55E−10 | 7.81E−05 | [28, 29] |
| 6 | cg25221975a | 3 | 13663444 | FBLN2 | Body | 4.27% | 5.07 | 5.58E−07 | 2.62 | 9.25E−03 | 5.48 | 4.29E−08 | 2.66E−03 | [29] |
| 7 | cg20414364 | 5 | 1608614 | LOC728613 | Body | 0.87% | 2.46 | 1.41E−02 | 5.61 | 3.99E−08 | 5.47 | 4.56E−08 | 2.66E−03 | |
| 8 | cg25998745a | 8 | 142028625 | NA | NA | 2.33% | −3.81 | 1.59E−04 | −3.98 | 8.30E−05 | −5.43 | 5.49E−08 | 2.80E−03 | [29, 65] |
| 9 | cg12825509 | 3 | 185648568 | TRA2B | Body | 3.52% | −4.61 | 5.10E−06 | −3.01 | 2.77E−03 | −5.40 | 6.62E−08 | 3.00E−03 | [29, 37] |
| 10 | cg03589820 | 3 | 11585825 | ATG7 | Body | 3.34% | 4.50 | 8.46E−06 | 3.00 | 2.92E−03 | 5.31 | 1.10E−07 | 3.87E−03 | |
| 11 | cg13866253 | 11 | 77093001 | PAK1 | Body | 2.02% | −3.45 | 6.13E−04 | −4.19 | 3.46E−05 | −5.31 | 1.12E−07 | 3.87E−03 | |
| 12 | cg15705813a | 2 | 70297499 | NA | NA | 1.78% | −4.13 | 4.27E−05 | −3.40 | 7.33E−04 | −5.30 | 1.14E−07 | 3.87E−03 | [28, 29] |
| 13 | cg19825437a | 3 | 169383292 | NA | NA | 3.64% | −4.69 | 3.45E−06 | −2.68 | 7.58E−03 | −5.25 | 1.52E−07 | 4.78E−03 | [28, 29] |
| 14 | cg02583484a | 12 | 54677008 | HNRNPA1; HNRPA1L-2 | Body | 2.34% | −3.78 | 1.74E−04 | −3.67 | 2.74E−04 | −5.22 | 1.77E−07 | 5.17E−03 | [28, 29, 65] |
| 15 | cg27376514 | 17 | 17058422 | MPRIP | Body | 2.64% | 4.03 | 6.48E−05 | 3.26 | 1.20E−03 | 5.14 | 2.77E−07 | 7.53E−03 | |
| 16 | cg18590502 | 3 | 49203081 | CCDC71 | 5UTR | 4.46% | −5.13 | 4.08E−07 | −2.00 | 4.65E−02 | −5.12 | 3.06E−07 | 7.82E−03 | [29] |
| 17 | cg19731612 | 5 | 176559334 | NSD1 | TSS1500 | 1.84% | −3.37 | 7.97E−04 | −3.93 | 1.02E−04 | −5.08 | 3.69E−07 | 8.18E−03 | [28, 29] |
| 18 | cg02256576 | 16 | 66995192 | CES3 | 5UTR | 2.61% | −3.98 | 7.93E−05 | −3.23 | 1.36E−03 | −5.08 | 3.80E−07 | 8.18E−03 | [28, 29] |
| 19 | cg23090529a | 1 | 51442133 | NA | NA | 2.64% | −4.03 | 6.51E−05 | −3.17 | 1.64E−03 | −5.08 | 3.81E−07 | 8.18E−03 | [29, 65] |
| 20 | cg25983901 | 7 | 46972700 | NA | NA | 2.94% | −4.18 | 3.45E−05 | −2.98 | 3.08E−03 | −5.07 | 4.09E−07 | 8.35E−03 | [28] |
| 21 | cg00944421 | 16 | 68269483 | ESRP2 | Body | 3.19% | −4.43 | 1.14E−05 | −2.65 | 8.51E−03 | −5.03 | 4.81E−07 | 9.35E−03 | |
| 22 | cg07167185 | 1 | 24120017 | LYPLA2 | Body | 1.19% | 2.82 | 5.01E−03 | 4.47 | 1.01E−05 | 5.02 | 5.11E−07 | 9.50E−03 | |
| 23 | cg13548452 | 14 | 22573606 | NA | NA | 2.44% | −3.82 | 1.51E−04 | −3.30 | 1.05E−03 | −5.01 | 5.46E−07 | 9.69E−03 | |
| 24 | cg00294109 | 3 | 3219781 | CRBN | Body | 1.89% | 3.43 | 6.44E−04 | 3.67 | 2.76E−04 | 4.96 | 6.91E−07 | 1.18E−02 | |
| 25 | cg23482898a | 3 | 12858887 | CAND2 | Body | 2.04% | 3.50 | 5.04E−04 | 3.56 | 4.10E−04 | 4.95 | 7.60E−07 | 1.24E−02 | [29] |
| 26 | cg23028286 | 15 | 51614521 | CYP19A1 | 5UTR | 3.40% | −4.52 | 7.61E−06 | −2.33 | 2.03E−02 | −4.89 | 9.85E−07 | 1.50E−02 | |
| 27 | cg19869698 | 17 | 80058686 | NA | NA | 3.88% | 4.73 | 2.86E−06 | 2.09 | 3.70E−02 | 4.89 | 9.91E−07 | 1.50E−02 | |
| 28 | cg11704631 | 21 | 36395663 | RUNX1 | Body | 2.96% | −4.16 | 3.66E−05 | −2.65 | 8.40E−03 | −4.84 | 1.29E−06 | 1.89E−02 | [29] |
| 29 | cg06983052 | 1 | 90288099 | LRRC8D | 5UTR | 2.37% | −3.78 | 1.73E−04 | −3.00 | 2.90E−03 | −4.79 | 1.69E−06 | 2.33E−02 | [28, 29] |
| 30 | cg01425762 | 16 | 81666633 | CMIP | Body | 0.87% | 2.44 | 1.49E−02 | 4.54 | 7.50E−06 | 4.79 | 1.71E−06 | 2.33E−02 | |
| 31 | cg24135793 | 19 | 13122567 | NFIX | Body | 2.00% | −3.49 | 5.18E−04 | −3.29 | 1.09E−03 | −4.76 | 1.90E−06 | 2.51E−02 | [29, 37] |
| 32 | cg00220102 | 16 | 8806756 | ABAT | TSS200 | 4.26% | −5.11 | 4.65E−07 | −1.47 | 1.44E−01 | −4.75 | 2.02E−06 | 2.58E−02 | |
| 33 | cg24351003 | 10 | 88013210 | GRID1 | Body | 1.97% | −3.46 | 5.90E−04 | −3.28 | 1.12E−03 | −4.73 | 2.22E−06 | 2.75E−02 | |
| 34 | cg22274745 | 2 | 182451537 | CERKL | Body | 1.95% | 3.51 | 4.88E−04 | 3.16 | 1.71E−03 | 4.69 | 2.73E−06 | 3.12E−02 | |
| 35 | cg08250921 | 16 | 88111009 | NA | NA | 3.20% | 4.42 | 1.19E−05 | 2.13 | 3.42E−02 | 4.69 | 2.76E−06 | 3.12E−02 | |
| 36 | cg24238409 | 10 | 93998677 | CPEB3 | Body | 2.92% | 4.26 | 2.43E−05 | 2.30 | 2.18E−02 | 4.68 | 2.79E−06 | 3.12E−02 | |
| 37 | cg13610455 | 20 | 37054900 | LOC388796; SNORA71B | TSS1500 | 1.59% | 3.16 | 1.65E−03 | 3.54 | 4.46E−04 | 4.68 | 2.85E−06 | 3.12E−02 | |
| 38 | cg10891521 | 17 | 81047941 | METRNL | Body | 1.04% | 2.63 | 8.80E−03 | 4.15 | 4.08E−05 | 4.68 | 2.93E−06 | 3.12E−02 | |
| 39 | cg14817906 | 2 | 97466833 | CNNM4 | Body | 2.66% | 4.05 | 5.88E−05 | 2.52 | 1.22E−02 | 4.67 | 2.97E−06 | 3.12E−02 | |
| 40 | cg24136754 | 22 | 37403978 | C22orf33 | TSS200 | 1.84% | 3.40 | 7.19E−04 | 3.20 | 1.49E−03 | 4.64 | 3.53E−06 | 3.60E−02 | |
| 41 | cg06925984 | 17 | 77767242 | NA | NA | 1.90% | −3.45 | 5.97E−04 | −3.12 | 1.92E−03 | −4.63 | 3.72E−06 | 3.61E−02 | |
| 42 | cg08616943 | 7 | 130552600 | NA | NA | 1.99% | −3.50 | 5.14E−04 | −3.07 | 2.28E−03 | −4.62 | 3.78E−06 | 3.61E−02 | |
| 43 | cg14395885 | 9 | 130700923 | DPM2 | TSS200 | 0.73% | −2.23 | 2.62E−02 | −4.53 | 7.91E−06 | −4.62 | 3.87E−06 | 3.61E−02 | |
| 44 | cg15033653 | 12 | 113587581 | CCDC42B | TSS200 | 3.14% | 4.41 | 1.26E−05 | 2.03 | 4.29E−02 | 4.62 | 3.89E−06 | 3.61E−02 | |
| 45 | cg20970380 | 1 | 116676103 | C1orf161 | 3UTR | 4.05% | −4.98 | 8.80E−07 | −1.39 | 1.66E−01 | −4.61 | 4.06E−06 | 3.68E−02 | |
| 46 | cg03044573a | 1 | 173835265 | GAS5; SNORD78; SNORD44; SNORD80; SNORD79 | TSS1500 | 0.97% | −2.98 | 3.05E−03 | −3.63 | 3.19E−04 | −4.60 | 4.20E−06 | 3.73E−02 | [29] |
| 47 | cg23598378 | 6 | 42072986 | C6orf132 | Body | 1.16% | 2.77 | 5.85E−03 | 3.86 | 1.34E−04 | 4.59 | 4.41E−06 | 3.77E−02 | [28] |
| 48 | cg06059663 | 1 | 245319431 | KIF26B | Body | 2.12% | −3.65 | 2.91E−04 | −2.85 | 4.67E−03 | −4.59 | 4.45E−06 | 3.77E−02 | |
| 49 | cg11302401 | 6 | 6688847 | NA | NA | 2.63% | −3.97 | 8.12E−05 | −2.47 | 1.38E−02 | −4.59 | 4.52E−06 | 3.77E−02 | |
| 50 | cg17840178 | 6 | 30709803 | FLOT1 | Body | 3.16% | −4.38 | 1.42E−05 | −2.01 | 4.55E−02 | −4.58 | 4.62E−06 | 3.78E−02 | |
| 51 | cg13966547 | 1 | 2406284 | PLCH2 | TSS1500 | 1.21% | −2.83 | 4.84E−03 | −3.76 | 1.97E−04 | −4.57 | 4.79E−06 | 3.82E−02 | |
| 52 | cg27477373 | 19 | 56879645 | ZNF542 | TSS200 | 1.81% | −3.35 | 8.71E−04 | −3.15 | 1.74E−03 | −4.57 | 4.93E−06 | 3.82E−02 | |
| 53 | cg06937549 | 5 | 179046350 | HNRNPH1 | Body | 2.33% | −3.76 | 1.87E−04 | −2.67 | 7.80E−03 | −4.56 | 5.05E−06 | 3.82E−02 | |
| 54 | cg26340050 | 14 | 105771879 | NA | NA | 3.41% | 4.54 | 7.13E−06 | 1.81 | 7.18E−02 | 4.56 | 5.08E−06 | 3.82E−02 | |
| 55 | cg05303280 | 15 | 51632611 | GLDN | TSS1500 | 3.46% | −4.55 | 6.73E−06 | −1.78 | 7.55E−02 | −4.56 | 5.22E−06 | 3.82E−02 | |
| 56 | cg21550372 | 14 | 100908908 | WDR25 | Body | 2.39% | −3.79 | 1.68E−04 | −2.63 | 8.90E−03 | −4.55 | 5.28E−06 | 3.82E−02 | |
| 57 | cg03840289 | 4 | 2262318 | MXD4 | Body | 1.72% | 3.25 | 1.25E−03 | 3.25 | 1.27E−03 | 4.55 | 5.33E−06 | 3.82E−02 | |
| 58 | cg17521665 | 6 | 106546704 | PRDM1 | TSS200 | 1.32% | −2.92 | 3.60E−03 | −3.59 | 3.76E−04 | −4.53 | 5.78E−06 | 3.90E−02 | |
| 59 | cg10692140 | 6 | 30496072 | NA | NA | 1.34% | −2.89 | 4.07E−03 | −3.63 | 3.21E−04 | −4.53 | 5.83E−06 | 3.90E−02 | |
| 60 | cg11599718 | 12 | 123357128 | VPS37B | Body | 1.29% | 2.89 | 4.05E−03 | 3.63 | 3.27E−04 | 4.53 | 5.89E−06 | 3.90E−02 | |
| 61 | cg00166216 | 3 | 194407860 | FAM43A | 1stExon | 2.20% | −3.69 | 2.44E−04 | −2.70 | 7.21E−03 | −4.53 | 5.91E−06 | 3.90E−02 | |
| 62 | cg23019886 | 12 | 6277045 | NA | NA | 2.22% | 3.68 | 2.58E−04 | 2.72 | 6.87E−03 | 4.53 | 5.92E−06 | 3.90E−02 | |
| 63 | cg17953300 | 11 | 65418265 | SIPA1 | 3UTR | 1.52% | 3.14 | 1.78E−03 | 3.33 | 9.63E−04 | 4.53 | 6.01E−06 | 3.90E−02 | |
| 64 | cg10440877 | 2 | 208378475 | NA | NA | 1.52% | −3.04 | 2.50E−03 | −3.43 | 6.71E−04 | −4.52 | 6.30E−06 | 3.98E−02 | |
| 65 | cg09801924 | 11 | 65425948 | RELA | Body | 1.23% | 2.77 | 5.90E−03 | 3.73 | 2.17E−04 | 4.51 | 6.51E−06 | 3.98E−02 | |
| 66 | cg19939130 | 1 | 158978468 | IFI16 | TSS1500 | 2.21% | −3.69 | 2.51E−04 | −2.68 | 7.72E−03 | −4.51 | 6.52E−06 | 3.98E−02 | |
| 67 | cg14259466 | 10 | 135090997 | ADAM8 | TSS1500 | 1.46% | 3.06 | 2.31E−03 | 3.39 | 7.76E−04 | 4.51 | 6.56E−06 | 3.98E−02 | |
| 68 | cg11846968 | 20 | 31823545 | PLUNC | TSS1500 | 0.84% | −2.36 | 1.89E−02 | −4.21 | 3.25E−05 | −4.51 | 6.62E−06 | 3.98E−02 | |
| 69 | cg18568145 | 1 | 155225764 | FAM189B | TSS1500 | 2.77% | −4.11 | 4.67E−05 | −2.19 | 2.88E−02 | −4.50 | 6.73E−06 | 3.99E−02 | |
| 70 | cg20699548 | 8 | 71060638 | NCOA2 | Body | 2.71% | −4.05 | 5.90E−05 | −2.24 | 2.57E−02 | −4.49 | 7.12E−06 | 4.15E−02 | |
| 71 | cg22537604 | 19 | 43857074 | CD177 | TSS1500 | 2.08% | −4.31 | 1.92E−05 | −1.93 | 5.37E−02 | −4.49 | 7.31E−06 | 4.19E−02 | |
| 72 | cg23747342 | 12 | 25539794 | NA | NA | 0.99% | 2.60 | 9.70E−03 | 3.89 | 1.19E−04 | 4.48 | 7.37E−06 | 4.19E−02 | |
| 73 | cg21845080 | 3 | 196065306 | TM4SF19 | TSS200 | 0.44% | 1.84 | 6.65E−02 | 4.76 | 2.77E−06 | 4.47 | 7.76E−06 | 4.29E−02 | |
| 74 | cg14728380 | 17 | 80280330 | SECTM1 | Body | 2.44% | 3.81 | 1.55E−04 | 2.48 | 1.36E−02 | 4.47 | 7.79E−06 | 4.29E−02 | |
| 75 | cg16423756 | 11 | 122526190 | UBASH3B | TSS1500 | 3.16% | 4.36 | 1.60E−05 | 1.86 | 6.31E−02 | 4.47 | 7.89E−06 | 4.29E−02 | |
| 76 | cg20732160 | 3 | 48590040 | PFKFB4 | Body | 2.58% | −3.99 | 7.58E−05 | −2.26 | 2.41E−02 | −4.46 | 8.13E−06 | 4.29E−02 | |
| 77 | cg00970435 | 17 | 66380327 | ARSG | Body | 1.11% | −2.67 | 7.82E−03 | −3.77 | 1.90E−04 | −4.46 | 8.16E−06 | 4.29E−02 | |
| 78 | cg09191335 | 20 | 35241157 | SLA2 | 3UTR | 2.24% | 3.66 | 2.77E−04 | 2.63 | 8.81E−03 | 4.46 | 8.18E−06 | 4.29E−02 | |
| 79 | cg15690475 | 17 | 44101453 | MAPT | Body | 1.86% | 3.38 | 7.68E−04 | 2.92 | 3.68E−03 | 4.44 | 8.82E−06 | 4.55E−02 | |
| 80 | cg27155460 | 10 | 45420821 | TMEM72 | Body | 2.70% | 4.03 | 6.52E−05 | 2.19 | 2.89E−02 | 4.44 | 8.91E−06 | 4.55E−02 | |
| 81 | cg09635954 | 7 | 29605624 | PRR15 | 5UTR | 0.80% | −2.35 | 1.94E−02 | −4.08 | 5.39E−05 | −4.42 | 9.82E−06 | 4.95E−02 | |
| 82 | cg03394159 | 8 | 29197844 | DUSP4 | Body | 1.90% | 3.32 | 9.79E−04 | 2.96 | 3.31E−03 | 4.42 | 1.01E−05 | 4.97E−02 | |
| 83 | cg21366673 | 6 | 30459512 | HLA-E | Body | 3.23% | −4.38 | 1.46E−05 | −1.76 | 7.92E−02 | −4.42 | 1.01E−05 | 4.97E−02 | [28] |
FDR: Benjamini–Hochberg false discovery rate; The CpGs in the table are significant (FDR < 5.00E−02) in meta-analysis.
aThe CpGs that are significant using African Ancestry sample in Liu et al. [29].