Table 3.
Diagnostic test parameters with 95% confidence intervals of the bone marrow biopsy and baseline FDG PET/CT results in comparison to the newly defined gold standard regarding bone marrow involvement, respectively
| PETAL n = 427 |
OPTIMAL>60 n = 503 |
Total n = 930 |
||||
|---|---|---|---|---|---|---|
| BMB versus reference standard | ||||||
| Sensitivity | 36/98 (37%) | (27%; 47%) | 49/123 (40%) | (31%; 49%) | 85/221 (38%) | (32%; 45%) |
| Specificity | 329/329 (100%) | (99%; 100%) | 380/380 (100%) | (99%; 100%) | 709/709 (100%) | (99%; 100%) |
| Positive predictive value | 36/36 (100%) | (90%; 100%) | 49/49 (100%) | (93%; 100%) | 85/85 (100%) | (96%; 100%) |
| Negative predictive value | 329/391 (84%) | (80%; 88%) | 380/454 (84%) | (80%; 87%) | 709/845 (84%) | (81%; 86%) |
| FDG PET/CT versus reference standard | ||||||
| Sensitivity | 88/98 (90%) | (82%; 95%) | 97/123 (79%) | (71%; 86%) | 185/221 (84%) | (78%; 88%) |
| Specificity | 329/329 (100%) | (99%; 100%) | 380/380 (100%) | (99%; 100%) | 709/709 (100%) | (99%; 100%) |
| Positive predictive value | 88/88 (100%) | (96%; 100%) | 97/97 (100%) | (96%; 100%) | 185/185 (100%) | (98%; 100%) |
| Negative predictive value | 329/339 (97%) | (95%; 99%) | 380/406 (94%) | (91%; 96%) | 709/745 (95%) | (93%; 97%) |
Abbreviations: BMB, bone marrow biopsy; FDG PET/CT, fluorine-18 fluorodeoxyglucose positron emission tomography/computed tomography