Table 4.

Simultaneous analysis of all possible predictors of endocrine toxicity by binary logistic regression analysis

		Statistical significance	Odd ratio	Odd Ratio C.I. (95%)		Probability	Probability C.I. (95%)
				Lower	Upper		Lower	Upper
Gender	Male	0.074	1.717	0.95	3.103	0.233	0.215	0.250
	Female					0.365	0.334	0.395
Tumor	NSCLC	0.284	0.799	0.53	1.204	0.298	0.277	0.320
	Melanoma					0.247	0.215	0.279
	Kidney					0.276	0.189	0.363
	Breast					0.320	0.177	0.464
	Head-Neck					0.125	0.073	0.177
	Bladder					0.120	0.120	0.120
Previous endocrinopathy	No	<0.001	4.156	2.141	8.065	0.216	0.209	0.223
	Yes					0.539	0.518	0.560
Anti PD-1	Pembrolizumab	0.902	1.039	0.57	1.894	0.289	0.260	0.318
	Nivolumab					0.279	0.257	0.302
Age	≤50	0.683	0.958	0.782	1.175	0.289	0.207	0.372
	51–55					0.250	0.214	0.285
	56–60					0.278	0.217	0.340
	61–65					0.311	0.258	0.363
	66–70					0.270	0.227	0.312
	>70					0.286	0.260	0.311

A result is considered statistically significant if it allows to reject the null hypothesis. A significance level of 5% was considered, namely all the results with a p value < 0.05 have a 5% probability that the null hypothesis is correct. Conversely, the same results have a 95% probability that the expected result is correct

C.I. Confidence Interval