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(A) Example of KCNQ2/3 mediated currents expressed in HEK293T cells at room and at near physiological temperature. Notice the slow activation kinetics independent of temperature. Bottom panel shows summary of conductance-to-voltage relationship of KCNQ2/3 current at room and near physiological temperatures. Independent of temperature KCNQ2/3 currents start activating at ~ −60 to −50 mV. The data were fit with a Boltzmann equation (unpublished data, Tzingounis).
