. Author manuscript; available in PMC: 2022 Apr 28.

Published in final edited form as: Dev Neurosci. 2021 Apr 28;43(3-4):143–158. doi: 10.1159/000515672

Table 2.

Summary of mouse models discussed in this review

Disorder	Animal model	Refs
TSC	Tsc1^−/− (germline KO)	[136]
	Tsc2^−/− (germline KO)	[137,138]
	Tsc1^+/− (germline Het)	[136,140–141],
	Tsc2^+/− (germline Het)	[137–138, 140,145,147]
	Tsc1^fl/fl;Emx1^Cre	[150]
	Tsc1^fl/fl;Syn1^Cre	[149]
	Tsc1^fl/fl;Camk2a^Cre	[151–152]
	Tsc1^fl/fl;GFAP^CreER	[154]
	Tsc1^fl/fl;L7^Cre	[155, 172]
	Tsc2^-/fl;L7^Cre	[156]
	Tsc1^fl/fl;Slc6a3^Cre	[158]
	Tsc1^fl/fl;Slc6a4^Cre	[159]
	Tsc1 ^{^fl/fl} ;Drd1a-Cre	[160[
	Tsc1 ^{^fl/fl} ;Adora2a-Cre	[160]
	Tsc1^fl/fl;Gbx2^CreER	[161]
	Tsc1^{^fl/fl}+ Cre in utero electroporation	[173]
	Tsc1^flox/-+ Cre in utero electroporation	[162]

PHTS	PTEN^−/− (germline KO)	[139]
	PTEN^+/− (germline Het)	[139,143–144, 180]
	PTEN ^fl/fl;CamK2a^Cre	[152–153]
	PTEN ^fl/fl;L7^Cre	[157]
	PTEN^fl/fl;Slc6a3^Cre	[143]
	PTEN^{^fl/fl} + AAV-Cre	[171]

PMSE	Strada^−/− (germline KO)	[133]
PMSE	Strada shRNA in utero electroporation	[132]

MCD	Depdc5^fl/fl;Syn1^Cre	[135]
	Rheb^CAin utero electroporation	[163, 170]
	Tsc1 CRISPR/Cas9 editing in utero electroporation	[82]
	Tsc2 CRISPR/Cas9 editing in utero electroporation	[82]

Listed are the primary mouse models discussed in this review. Comprehensive reviews of animal models of mTORopathies can be found in references [12, 134, 142, 148]