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. Author manuscript; available in PMC: 2022 Oct 1.
Published in final edited form as: Eur J Nucl Med Mol Imaging. 2021 Apr 10;48(11):3522–3529. doi: 10.1007/s00259-021-05302-6

Fig. 4. Comparison of the concordance of clinical and PET diagnoses with autopsy.

Fig. 4

At the time of PET referral, in patients with uncertain clinical diagnosis (mean symptom duration 4 years), the referral diagnosis agreed with autopsy only 67% of the time. Automated classification based on contemporaneous PET imaging increased diagnostic accuracy to 80% for Level 1 and 87.5% for Level 2. The final clinical diagnosis, reached by the expert clinician after an average of 2 years of follow-up, was 93% concordant with autopsy findings obtained approximately 2 years later.