Table 1:
Physiological and hemodynamic parameters of each piglet.
| piglet # | Treatment | Time after injury (hour) | Hct (%) | EtCO2 (mmHg) | TRUPC | PC | VSASL | ||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| OEF (ICV) (%) | OEF (SSS) (%) | CBF (ml/min/100g) | CMRO2 (μmol/min/100g) | rCBF | CBF (ml/min/100g) | CMRO2 (μmol/min/100g) | |||||
| 1 | Sham | 168 | 21.6 | 34.5 | 48.1 | 61.2 | 27.3 | 75.9 | N/A | N/A | N/A |
| 2 | Sham | 23 | 22.5 | 38.0 | 52.8 | 55.4 | 19.9 | 51.9 | 1.5 | 35.7 | 93.3 |
| 3 | QA (240 nmol) | 96 | 24.1 | 36.0 | 46.3 | 63.4 | 21.5 | 68.9 | 1.3 | 21.9 | 70.3 |
| 4 | QA (720 nmol) | 96 | 24.3 | 34.0 | N/A | 68.5 | 10.7 | 37.4 | N/A | 22.2 | 77.4 |
| 5 | QA (720 nmol) | 91 | 24.3 | 36.0 | 52.7 | 59.1 | 36.3 | 109.4 | 1.4 | 22.2 | 67.1 |
| 6 | QA (720 nmol) | 20 | 16.8 | 46.5 | 49.1 | 48.5 | 55.4 | 94.8 | 0.9 | 43.3 | 74.2 |
| 7 | QA (960 nmol) | 25 | 23.4 | 77.5 | 21.2 | 21.3 | 279.3 | 292.3 | 0.7 | 64.4 | 67.4 |
| 8 | QA (960 nmol) | 24 | 20.4 | 42.0 | 37.9 | 43.1 | 45.0 | 83.1 | 0.8 | 36.8 | 68.0 |
| 9 | HI | 45 | 23.4 | 43.0 | 41.4 | 49.1 | N/A | N/A | 0.8 | 28.5 | 68.8 |
| 10 | HI | 65 | 28.4 | 39.0 | 40.5 | 45.5 | 41.1 | 111.5 | 0.9 | 36.4 | 98.7 |
| Mean | 22.9 | 38.8 | 46.1 | 54.9 | 32.1 | 79.1 | 1.1 | 30.9 | 77.2 | ||
| Std | 3.2 | 4.3 | 5.6 | 8.8 | 14.9 | 26.2 | 0.3 | 8.3 | 12.2 | ||
| CoV (Std/Mean, %) | 14.0 | 11.1 | 12.2 | 16.0 | 46.4 | 33.1 | 28.3 | 26.9 | 15.8 | ||
QA: quinolinic acid injection; HI: global hypoxia-ischemia; Hct: hematocrit; EtCO2: end-tidal carbon dioxide; TRUPC: T2-relaxation-under-phase-contrast; PC: phase contrast; VSASL: velocity-selective arterial spin labeling; OEF: oxygen extraction fraction; SSS: superior sagittal sinus; ICV: internal cerebral vein; CBF: global cerebral-blood-flow for PC or whole-brain averaged CBF for VSASL; rCBF is the relative CBF of putamen and caudate of right side to the left side; CMRO2: cerebral metabolic rate of oxygen of the whole brain; Std: standard deviation; CoV: coefficient of variation; N/A: data not acquired. Piglet #7 was considered as an outlier due to almost twice-of-average EtCO2, and excluded from the statistical analyses.