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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Neurotoxicology. 2021 Jul 2;86:26–36. doi: 10.1016/j.neuro.2021.06.008

Figure 3. Barnes maze (PND 385), Open Field Test (PND 385), and Immunohistochemical data (PND 75).

Figure 3.

(A-B) On PND 385, male and female mice were analyzed for cognitive impairment or locomotor differences using the Barnes maze acquisition trials (A) and the probe trial (B) with an ‘n’ of at least 9. In the SDVH group, there were 6 males and 12 females, and, in the SDPFOS group, there were 4 males and 5 females. (C) On PND 75, male mice (n=3 per treatment group) were anesthetized and transcardially perfused. Brains were stained using H&E, CSAD, and AT8 staining solutions, respectively. These images of control brains (top), and developmentally exposed mice (bottom) are representative. (D-F) Male and female mice were analyzed during the open field test for the time spent in the center (D), the number of times reared (E), and the distance traveled (F). Results are expressed as mean ± SEM using either a two-way ANOVA (A) or a parametric two-tailed unpaired t-test with Welch’s correction (B, D-F). *p < 0.05, **p<0.01, ***p < .001, ****p < .0001 was considered significant.