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. Author manuscript; available in PMC: 2022 Sep 1.
Published in final edited form as: Neurotoxicology. 2021 Jul 2;86:26–36. doi: 10.1016/j.neuro.2021.06.008

Figure 4. APP mRNA and protein levels at PND 20 in the cortex of CD-1 mice developmentally exposed to PFOS (amyloidogenic pathway).

Figure 4.

Timed-pregnant CD-1 mice were administered with vehicle (0.5% Tween-20 in water) or 1 mg/kg/day PFOS in water with 0.5% Tween-20 via oral gavage from gestation GD 1 through postnatal day PND 20. (A-B) quantification of APP protein levels normalized to GAPDH. (C) APP mRNA levels. (D-E) quantification of Aβ 1-42 and Aβ 1-40 protein levels normalized to GAPDH. (F) Aβ 1-42: Aβ 1-40 ratio. Results are expressed as mean ± S.E.M using the two-tailed unpaired t-test, n=4. Results were non-significant.