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. Author manuscript; available in PMC: 2022 Sep 27.
Published in final edited form as: J Perinat Med. 2021 Apr 20;49(7):897–906. doi: 10.1515/jpm-2021-0049

Figure 1. Intra-amniotic injection of HMGB1 guided by ultrasound.

Figure 1.

(A) Experimental design: Dams were intra-amniotically injected with HMGB1 (9 ng/100 μL) or PBS (100 μL) on 14.5 days post coitum (dpc) and observed until birth. Color Doppler was used to identify the “injection jet sign.” (B) Gestational length of dams injected with vehicle (blue dots) or HMGB1 (red dots) (n = 9-10 each). Data are shown as boxplots where the midline represents the median, boxes represent interquartile range, and whiskers represent the minimum/maximum range. (C) Preterm birth rate (<19 dpc) for dams that received vehicle (blue dots) or HMGB1 (red dots) (n = 9-10 each).