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. Author manuscript; available in PMC: 2022 Sep 10.
Published in final edited form as: J Control Release. 2021 Jul 27;337:458–471. doi: 10.1016/j.jconrel.2021.07.042

Figure 3.

Figure 3.

A) Representative axial (top row) and coronal (bottom row) contrast enhanced T1w MRI images after FUS-induced BBB opening using the cavitation-based controller system for the three different CCDtargets. B) Average BBB permeability enhancement volume 30 minutes after gadolinium injection. Statistically significant volumes of enhancement were found in all three CCDtargets groups (One-way ANOVA with Tukey corrected post-hoc comparisons). All error bars represent SEM. * - p < 0.05, ** p < 0.01, ****p < 0.0001. C) Representative axial contrast enhanced T1w MRI images over three time points (0.5 h, 48 h, and 72 h) for all three CCDtargets. The BBB closing timeline varied depending on CCDtargets, ranging from closing within 48 h for lCCD, to being still opened at 72 h for hCCD.