Table 1.

Characterization of microbubble formulations used for clinical imaging with Definity, ten times (10x) the clinical imaging dose of Definity, and previously published reports showing effective FUS-induced BBB opening.

Reference	Bubble Distribution	Bubble Size	Bubble Concentration	Bubble Dosage	Bubbles per bolus injection (million)
Clinical Definity	Polydisperse	1.1 – 3.3 µm	1.2 × 1010/mL	0.01 µL/g	3
10x Clinical Definity	Polydisperse	1.1 – 3.3 µm	1.2 × 109/mL	1.0 µL/g	30
Samiotaki et al. 2013 [12]	Polydisperse	1.1 – 3.3 µm	6.0 × 108/mL	1.0 µL/g	15
Choi et al. 2010 [17]	Size isolated	4 – 5 µm	8.5 × 108/mL	0.9 µL/g	19
Olumolade et al. 2016 [26]	Polydisperse	~1.4 µm	8.0 × 108/mL	1.0 µL/g	20
Wu et al. 2015 [37]	Size isolated	4 – 5 µm	8.0 × 108/mL	1.2 – 1.5 µL/g	24 – 30