Table 2.
Exosome-mediated delivery of various therapeutic cargos.
| Class of cargo | Cargo | Reference |
|---|---|---|
| TNAs | siRNA against RAD51 and RAD52 | Shtam et al., Commun.signal., 2013 |
| siRNA against MAPK1 | Wahlgren et al., Nucleic Acids Res., 2012 | |
| siRNA against luciferase | Banizs et al., Int J Nanomedicine, 2014 | |
| siRNA against GAPDH | Alvarez-Erviti et al., Nat. Biotec., 2011 | |
| siRNA against CD81 | Pan et al., Gut, 2012 | |
| siRNA against Huntingtin | Didiot et al., Mol Ther., 2016 | |
| miR-214 | Chen et al., Hepatology, 2013 | |
| miR-150 | Zhang et al., Mol.Cell, 2010 | |
| miR-146b | Katakowski et al., Cancer Lett., 2013 | |
| miR-143 | Kosaka et al., J.Biol. Chem., 2012 | |
| miR-133b | Xin et al., Stem Cell, 2012 | |
| miR-124 | Yang et al., Mol Ther. Nuc Acids, 2017 | |
| miR-335 | Mittelbrunn et al., Nature com., 2011 | |
| miR-138 | Li et al., Mol Ther. Nuc Acids, 2019 | |
| EBV-miR | Pegtel et al., Proc Natl Acad Sci USA, 2010 | |
| Let-7a miRNA | Ohno et al., Mol Ther., 2013 | |
| Cy5-anti-miR-9 | Munoz et al., Mol. Ther. Nuc Acids, 2013 | |
| CpG DNA | Morishita et al., Biomaterials, 2016 | |
| DNA | Lamichhane et al., Mol. Pharmaceutics, 2015 | |
| NGF mRNA | Yang et al., Mol Ther. Nuc Acids, 2020 | |
| Proteins | catalase | Haney et al., J Control Release, 2015 |
| porphyrin | Fuhrmann et al., J Control Release, 2015 | |
| Lipids | liposome | Sato et al., Sci Rep., 2016 |
| Small molecules | Curcumin | Sun et al., Mol. Ther., 2010 |
| Doxorubicin | Tian et al., Biomaterials, 2013 | |
| Paclitaxel | Agrawal et al., Nanomedicine, 2017 | |
| Paclitaxel and doxorubicin | Yang et al., Pharm Res., 2015 | |
| Olaparib | Jung et al., Biomaterials, 2018 | |
| Nanoparticles | NANPs functionalized with multiple RNAi inducers and NF-kB decoys | Nordmeier et al., Nanomedicine: Nanotechnology, Biology and Medicine, 2020 |
| superparamagnetic iron oxide nanoparticles (SPION5) | Hood et al., Analytical biochemistry, 2014 | |
| Metal-organic framework nanoparticles | Illes et al., Chem.Mater, 2017 | |
| 3WJ arrowtail RNA Nanoparticle contain siRNA against survivin | Pi et al., Nature Nanotechnology, 2018 | |
| dexamethasone sodium phosphate (Dex) nanoparticle | Yan et al., J Nanobiotechnol, 2020 | |
| Other | Adeno-associated viral vector | Maguire et al., Mol. Ther., 2012 |
| JSI-124 | Zhuang et al., Mol. Ther., 2011 | |
| CRISPR/Cas9 | Lin et al., Adv Sci., 2018 |