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Tumor-derived factors elicit a multi-factorial response in myoblasts including disrupted proliferation, differentiation, cell death, and protein homeostasis. These processes lead to dysfunctional myogenesis, which may contribute to skeletal muscle wasting in cancer cachexia. Our study showed that TNFα and IFNγ have complex effects on myoblasts, but a single inhibitor for NOS2, 1400W, is able to reverse these effects and restore myogenesis. Created with BioRender.com.
