Fig. 5.

AIM2 regulates Blimp-1 and Bcl-6 expression and directly binds to Blimp-1 and Bcl-6. a AIM2 expression was knocked down in B cells by AIM2 ASO, and the mRNA expression of Bcl6, Pax5, Xpb1, Mta3, Cd27, Cd38, Blimp-1, and Irf4 was detected by qRT-PCR. b Blimp-1 expression was knocked down in B cells by Blimp-1 siRNA, and the mRNA expression of Bcl6, Pax5, Xpb1, Mta3, Cd27, Cd38, Aim2, and Irf4 was detected by qRT-PCR. c The Co-IP of AIM2 with Blimp-1, Bcl-6, and ASC. d The nuclear expression of AIM2 in human tonsil B cells. Horizontal bars represent the mean ± SEM. *p < 0.05, **p < 0.01, ***p < 0.005, ****p < 0.0001