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. 2021 Sep 14;12:5435. doi: 10.1038/s41467-021-25742-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 3 — a LRRC8A/Sb1 complex at 3.1 Å. b LRRC8A/Sb2 complex at 3.5 Å. c LRRC8A/Sb3 complex at 3.3 Å. d LRRC8A/Sb4 complex at 3.8 Å. e LRRC8A/Sb3 complex at 3.8 Å. a–e Subunits at left and right positions in the C3-symmetric channels are colored in green and beige, respectively. Sybodies are shown in unique colors, residual density of the detergent micelle in gray. Binding of sybodies to all six subunits in case of the complexes with Sb1, Sb2 and Sb3, and to the subunits at r-positions in case of complexes with Sb4 and Sb5 is apparent.