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. 2021 Sep 14;12:5435. doi: 10.1038/s41467-021-25742-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a Surface representation of the LRRC8A/Sb1 complex structure. b Structure of the dimer of interacting domains at the tight interface with bound sybody Sb1. Left (l) and right (r) positions are indicated. c Ribbon representation of the LRRC8A/Sb1 complex. a, c The view is from within the membrane with membrane boundaries indicated. d Ribbon representation of a single LRR domain with sybody Sb1 bound. Repeats contacted by Sb1 are labeled. e View on the interaction interface of Sb1 and f the LRRC8A domain. The protein is shown as Cα trace with the sidechains of interacting residues displayed as sticks.