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. 2021 Sep 14;12:5435. doi: 10.1038/s41467-021-25742-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Surface representation of the LRRC8A/Sb2 complex structure. b Structure of the dimer of interacting domains at the tight interface with bound sybody Sb2. c Surface representation of the LRRC8A/Sb3 complex structure. d Structure of the dimer of interacting domains at the tight interface with bound sybody Sb3. b, d Left (l) and right (r) positions are indicated. e Ribbon representation of a single LRR domain with bound sybodies Sb2 and Sb3. Repeats contacted by both sybodies are labeled. f View on the interaction interface of a homology model of Sb2 based on the Sb3 structure, g the LRRC8A domain and, h Sb3. The protein is shown as Cα trace with the sidechains of interacting residues displayed as sticks.