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. 2021 Sep 14;12:5435. doi: 10.1038/s41467-021-25742-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a LRRC8A/Sb1 complex, b LRRC8A/Sb2 complex, c LRRC8A/Sb3 complex. a–c Shown are surface representations of domain pairs at the tight interface (top) with contact regions with bound sybodies colored and the hexameric assembly of the domains viewed from the cytoplasm with symmetry axis indicated as triangle (bottom). Insets (top right) display Cα trace of the right subunit of the respective structure, which is superimposed in b and c on the respective structure of the complex with sybody Sb1. d Surface representation of the pore domain of the LRRC8A/Sb1 (top) and the LRRC8A/Sb3 complex (bottom) viewed from within the membrane.