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. 2021 Sep 14;12:5435. doi: 10.1038/s41467-021-25742-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — a Surface representation of the LRRC8A/Sb4 complex structure. b Structure of the dimer of interacting domains at the loose interface with bound Sb4. c Surface representation of the LRRC8A/Sb5 complex structure. d Structure of the dimer of interacting domains at the loose interface with bound Sb5. b, d Left (l) and right (r) positions are indicated. e Ribbon representation of a single LRR domain with bound sybodies Sb4 and Sb5. Repeats contacted by one of the two sybodies are labeled. a–e Due to the low resolution of cryo-EM densities of binders in the respective maps, Sb4 and Sb5 structures are based on homology models of both sybodies.