Table 3.
Association between life-course trajectories of weight categories and cumulative incidence of type 2 diabetes.
| Risk ratios (RR) | Women | Men | ||
|---|---|---|---|---|
| Unadjusted RR (95%CI) |
Adjusted RR (95%CI) |
Unadjusted RR (95%CI) |
Adjusted RR (95%CI) |
|
| Stable normal weight | 1 (ref) | 1 (ref) | 1 (ref) | 1 (ref) |
| Stable overweight | 3.69 (2.76–4.95) | 2.77 (2.06–3.73) | 2.94 (2.12–4.08) | 2.68 (1.92–3.75) |
| Lean increasing weight | 1.98 (1.50–2.60) | 1.71 (1.31–2.24) | 1.32 (0.96–1.81) | 1.35 (0.98–1.85) |
| Overweight from early adulthood | 4.07 (3.25–5.11) | 3.43 (2.72–3.34) | 3.03 (2.40–3.84) | 2.77 (2.17–3.54) |
| Overweight from late adulthood | 2.78 (2.13–3.63) | 2.27 (1.75–2.95) | 1.76 (1.29–2.40) | 1.73 (1.26–2.37) |
| Absolute risk difference (ARD) | Unadjusted ARD% (95%CI) |
Adjusted ARD% (95%CI) |
Unadjusted ARD% (95%CI) |
Adjusted ARD% (95%CI) |
|---|---|---|---|---|
| Stable normal weight | 0 (ref) | 0 (ref) | 0 (ref) | 0 (ref) |
| Stable overweight | 10.90% (6.97%–14.83%) | 7.94% (4.65%–11.24%) | 15.05% (7.89%–22.21%) | 13.11% (6.24%–19.99%) |
| Lean increasing weight | 3.35% (1.34%–5.27%) | 2.46% (0.57%–4.36%) | 3.92% (0.05%–7.36%) | 4.61% (0.95%–8.28%) |
| Overweight from early adulthood | 9.03% (6.63%–11.40%) | 7.76% (5.36%–10.17%) | 15.23% (11.52%–18.95%) | 14.05% (10.30%–17.79%) |
| Overweight from late adulthood | 5.02% (2.66%–7.38%) | 3.512% (1.36%–5.68%) | 4.84% (0.85%–8.82%) | 5.23% (1.03%–9.43%) |
Models for males and females were estimated separately. Covariates included in the adjusted model for were age, family history of type 2 diabetes, general health, comorbidities, self-reported physical activity, smoking, and alcohol consumption for both sexes and history of gestational diabetes for women. Adjusted absolute risk differences were estimated using the mean of all covariates.