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. 2021 Sep 14;7:85. doi: 10.1038/s41421-021-00314-w

Fig. 3. A unique B cell subpopulation associated with AChR antibody and disease activity in MG patients.

Fig. 3

a Volcano plot showing DEGs between MG patients and HCs. DEG: |log fold change| > 0.5; P value < 0.05 was calculated using DESeq2. b Enrichment analysis of DEGs from B cells between MG patients and HCs (selected among upregulated pathways in MG patients, P value < 0.05). c, d CD180− B cells are increased in MG patients. e, f CD180− B cells are the major IgG secreting cells in MG patients and HCs. CD180− IgG cells are significantly higher than CD180+ IgG cells in MG patients. g Circulating CD180− B cells are associated with disease activity. h Circulating CD180− B cells are associated with titers of anti-AChR antibodies. i Immunotherapy decreases CD180− B cells and is associated with improved disease activity.