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. 2021 Sep 14;7:85. doi: 10.1038/s41421-021-00314-w

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a UMAP plot displaying myeloid cells from two MG patients and two HCs separated into 9 subtypes. b Violin plots showing key gene markers across myeloid cells. c 3D diffusion map displaying the developmental trajectory of myeloid cells. The result shows the possible activation paths of macrophages/cDCs. Cells are colored by their derived clusters. pDCs, plasmacytoid dendritic cells; cDCs, conventional DCs. d Enrichment analysis of DEGs in dendritic cells between MG patients and HCs (selected among upregulated pathways in MG patients, P value < 0.05). e GSVA analysis of CD14⁺ monocytes between MG patients and HCs. f Dot plot of selected significant paracrine receptor-ligand interactions between CD14⁺/CD16⁺ monocytes and cDCs discovered using Cellchat. Commun.Prob., communication probability.