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. 2021 Sep 1;12:722017. doi: 10.3389/fphar.2021.722017

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Copyright © 2021 Ouyang, Liu, Lu, Liang, Zhao and Yang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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qRT-PCR determination of the relative circ_0005198 expression and its potential target miRNAs in RA-FLSs and OA-FLSs. (A): The level of circ_0005198 in OA-FLSs was significantly lower than that in RA-FLSs; (B): The level of circ_0005198 in RA-FLSs correlated with DAS28; (C,D): The level of miR-4459 and miR-1237-3p were not significantly different among RA-FLSs and OA-FLSs; (E): The RA-FLSs level of miR-4778-3p was decreased significantly compared with its OA-FLSs level; (F): The level of circ_0005198 in RA-FLSs correlated negatively with the level of miR-4778-3p.