TABLE 1.

Proteins used in this study together with their corresponding PDB IDs and their ligands used to calculate residue fluctuations in the bound state. Here ligand 46A represents N-butyl-4,6-dimethyl-N-{[2’-(2H-tetrazol-5-yl)biphenyl-4-yl]methyl}pyrimidin-2-amine, NAI represents 1, 4-Dihydronicotinamide adenine dinucleotide, C2E represents 9,9’-[(2R,3R,3aS,5S,7aR,9R,10R,10aS,12S,14aR)-3,5,10,12-tetrahydroxy-5,12-dioxidooctahydro-2H,7H-difuro[3,2-d:3′,2′-j][1,3,7,9,2,8]tetraoxadiphosphacyclododecine-2,9-diyl]bis(2-amino-1,9-dihydro-6H-purin-6-one), PPS represents 3’-Phosphate-adenosine-5’-phosphate sulphate, GTP represents Guanosine-5’-triphosphate, S1A represents Soraphen A, ATP represents Adenosine-5’-triphosphate, AMP represents Adenosine monophosphate, MG represents magnesium ion, RFZ represents 5,6-dichloro-1-beta-d-ribofuranosyl-1H-benzimidazole, and FBP represents 1,6-di-O-phosphono-beta-d-fructofuranose.

Protein	PDB ID	Ligand used
Mitogen-activated protein kinase 8	3O2M	46A
Citrate synthase	4JAF	NAI
Uncharacterized protein VCA0042	2RDE	C2E
ATP sulfurylase	1M8P	PPS
Glutamate dehydrogenase	3ETE	GTP
Acetyl-Coenzyme A carboxylase	1W96	S1A
Isocitrate dehydrogenase kinase/phosphatase	3EPS	ATP, AMP, MG
Casein kinase II subunit alpha	3H30	RFZ
l-lactate dehydrogenase	2LDB	FBP