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. 2021 Sep 1;8:724846. doi: 10.3389/fcvm.2021.724846

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Copyright © 2021 Li, Chen, Liu, Zhang, Chen, Chen, Chen, Yao, Hu, Wang and Wu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Developmental angiogenesis requires the mitochondrial phenylalanyl-tRNA synthetase. An overview of the mechanisms by which the deficiency of mitochondrial phenylalanyl-tRNA synthetase impairs angiogenesis by disrupting the Notch/Wnt pathways in zebrafish and human umbilical vein endothelial cells.