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Graphical summary of the findings of the present study. Our study demonstrates that IL-17 and CCR9+α4β7– Th17 cells promote salivary gland inflammation and dysfunction in SS. RA ameliorates aging- and metabolic-abnormality-induced salivary gland inflammation by inducing gut-homing CCR9+α4β7+ Th17 and Treg cells in SS.
