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. 2021 Sep 1;15:724891. doi: 10.3389/fnins.2021.724891

FIGURE 1.

FIGURE 1

Oligodendroglial pathology in TDP-43 and FUS proteinopathies. (A) Glial cytoplasmic inclusions (GCI) are a characteristic feature with presence in variable amounts in affected brain regions in ALS—TDP, in subtypes of FTLD—TDP (particularly types B, E), subtypes of ALS—FUS (particularly in pattern 1 associated with adult onset and longer disease duration), and all distinct entities of FTLD—FUS, including aFTLD-U, basophilic inclusion body disease, and neuronal intermediate filament inclusion disease. Semiquantitative scores: 0, absent;+, rare;++, moderate; +++, abundant. (B–E) Immunohistochemistry of human postmortem tissues with pTDP-43 S409/410 antibody (Neumann et al., 2009a) demonstrating numerous GCI (arrowheads) in spinal cord of ALS—TDP case (B) and frontal cortex of FTLD—TDP type B case (C), and FUS (Proteintech) immunohistochemistry demonstrating GCI in spinal cord of ALS-FUS case with pattern 1 pathology (D) and basal ganglia of FTLD—FUS (basophilic inclusion body disease) case (E) in addition to neuronal cytoplasmic inclusions (arrow). Scale bar in panel B = 20 μm.