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Schematic of potential mechanisms of oligodendrocyte dysfunction in pathogenesis of TDP-43/FUS proteinopathies. TDP-43 and FUS pathology in oligodendrocytes might modulate oligodendrocyte biology by binding to several transcripts (1a) and regulating pre-mRNA splicing (1b). Furthermore, it might affect transport of key RNA transcripts such as Mbp (2) and perturb bidirectional communication with axons (3). Created with BioRender.com.
