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. 2021 Sep 1;12:666430. doi: 10.3389/fneur.2021.666430

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Copyright © 2021 Wu, Kumal, Lu, Li, Mao, Tang, Nie, Liu, Sun, Liu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The cognitive function of APP/PS1 mice deteriorated after TBI. Quantitative analyses of the discrimination indexes of C57BL/6, C57BL/6 TBI, APP/PS1, and APP/PS1 TBI group mice in the acquisition (A) and test phases (B) in the NOR test (n = 8/group). Quantitative analyses of the discrimination indexes of C57BL/6, C57BL/6 TBI, APP/PS1, and APP/PS1 TBI group mice in the acquisition (C) and test phases (D) in the OPR test (n = 8/group). ns, non-significant; ^*p < 0.05; ^**p < 0.01.