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. 2021 Sep 1;12:666430. doi: 10.3389/fneur.2021.666430

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Copyright © 2021 Wu, Kumal, Lu, Li, Mao, Tang, Nie, Liu, Sun, Liu and Zhang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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TBI aggravated Aβ plaque deposition in the hippocampus in the APP/PS1 mouse model. (A) Representative IHC images of hippocampal (CA1, CA2, CA3, and DG) tissues from C57BL/6, C57BL/6 TBI, APP/PS1, and APP/PS1 TBI group mice immunostained for Aβ plaques. (B) Quantitative analyses of Aβ plaque deposition in the CA1, CA2, CA3, and DG regions of the hippocampus in C57BL/6, C57BL/6 TBI, APP/PS1, and APP/PS1 TBI mice. The error bars represent the SEM (n = 8/group). ns, nonsignificant; ^*p < 0.05; ^***p < 0.001.